research
Research conducted at the GUGC focuses on understanding of various mechanisms underlying B cell dis-function and vaccine failure against parasitic and bacterial diseases. In particular, we are interested in the events triggering apoptosis in B cells and causing loss of memory responses. Various gene candidates are being analyzed with the purpose of identifying rescue gene targets capable of preventing B cells depletion. In the context of vaccine design, research includes identification of novel pattern associated molecular patters (PAMPs) and their interactions with corresponding pattern recognition receptors (PRRs). Moreover, conducted vaccination studies also involve analyzing the role of mucosal immunity and microbiome functions. Currently, various research projects are performed in collaboration with Incheon National University, South Korea and the Vrije Universiteit Brussel (VUB), Belgium.
At the VUB, Prof. Magez is currently the head of the research unit for Structural and Functional Immuno-parasitlogy at the Laboratory for Cellular and Molecular Immunology. The close collaboration between the GUGC and VUB laboratories allows a regular exchange of researchers. In Brussels, a group of 2 post-doctoral researchers, 5 PhD fellows and 3 MSc students focus on various aspects of host-parasite interactions, combining immunology and structural biology approaches. The link between the laboratories is crucial for developing new research lines directed towards anti-trypanosome drug screening, nanobody-based diagnostic development and the unravelling of the molecular immunology of host-parasite interactions in South Korea.